Table 2.

Summary of American Cancer Society Recommendations for Screening of Moderate- or High-Risk Individuals

Test	One First-Degree Relative with Colon Cancer	Two or More First-Degree Relatives with Colon Cancer	Familial Adenomatous Polyposis (FAP)	Hereditary Nonpolyposis Colon Cancer (HNPCC)
Fecal occult blood testing (FOBT)	At 40 and then annually
Flexible sigmoidoscopy	At 40 and every 5 years		At puberty and annually until 35, then every 3 years
Double-contrast barium enema	At 40 and every 5 years, as an alternative to colonoscopy
Colonoscopy	At 40 and every 10 years	At 40 or 10 years younger than first diagnosis and every 5 years		Annually at 20–25 or 10 years younger than earliest diagnosis