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Thiopurine metabolism: azathioprine (AZA) is converted in the body to 6-mercaptopurine (6-MP). 6-MP is metabolized along three competing pathways. (1) Xanthine oxidase (XO) yielding thiouric acid (6-TU), (2) thiopurine methyltransferase (TPMT) yielding 6-methylmercaptopurine (6-MMP), and (3) hypoxanthine-guanine phosphoribosyltransferase (HPRT) yielding 6-thioguanine nucleotides (6-TGN).
