Table 1.
Summary of Existing Trials Investigating the Effect of Fluid Restriction during the Perioperative Period in Patients Undergoing Colorectal Surgery
| Author | Study Design | Perioperative Period Studied | Volume Administered | Effect of Fluid Restriction | Primary Endpoints/Results |
|---|---|---|---|---|---|
| DB, double blind; MCT, multicenter trial; RCT, randomized controlled trial. | |||||
| Brandstrup13 | DB, Randomized MCT | Intraoperative and postoperative | 2.7 L vs. 5.4 L | Beneficial | Fewer complications in restricted group |
| Nisanevich14 | RCT | Intraoperative | 1.2 L vs. 3.7 L | Beneficial | Mortality no different |
| Fewer complicatins in restrictive group | |||||
| Lobo24 | RCT | Postoperative | 3.1 L vs. 5.8 L | Beneficial | Gastric emptying time improved in restrictive group |
| Holte15 | DB, RCT | Intraoperative | 1.6 L vs. 5 L | Beneficial | Pulmonary funciion improved in restrictive group |
| Mackay25 | DB, RCT | Postoperative | 4.5 L vs. 8.75 L | No Effect | Hospital length of stay unchanged |
| Campbell10 | RCT | Intraoperative | 5–10 mL/kg/h vs. 10–15 mL/kg/h | Harmful | Reduced hemodynamic stability and urine output in restrictive group |
| Arkilic27 | RCT | Intraoperative | 2.8 L vs. 5 L | Harmful | Decreased tissue perfusion and oxygen tension in restrictive group |