Table 3.
Dose-ramped infusions of urantide
| Variable | Baseline | Urantide 0.1 pmol min−1 | Urantide 1.0 pmol min−1 | Urantide 10 pmol min−1 | Urantide 100 pmol min−1 | Significance of trend |
|---|---|---|---|---|---|---|
| Systolic BP (mmHg) | 113 ± 4 | 116 ± 5 | 119 ± 5 | 120 ± 5 | 120 ± 4 | 0.002 |
| Diastolic BP (mmHg) | 66 ± 3 | 68 ± 3 | 69 ± 3 | 70 ± 3 | 70 ± 3 | 0.308 |
| Mean arterial pressure (mmHg) | 82 ± 3 | 84 ± 3 | 86 ± 3 | 87 ± 3 | 87 ± 3 | 0.022 |
| Heart rate (bpm) | 48 ± 2 | 50 ± 2 | 49 ± 2 | 49 ± 1 | 50 ± 1 | 0.112 |
| Absolute FBF in infused arm (ml 100 ml−1 min−1) | 2.60 ± 0.37 | 2.65 ± 0.35 | 2.80 ± 0.37 | 3.02 ± 0.42 | 3.14 ± 0.38 | 0.002 |
| Ratio (infused/control arm) | 1.27 ± 0.14 | 1.24 ± 0.11 | 1.21 ± 0.10 | 1.16 ± 0.10 | 1.16 ± 0.11 | 0.214 |
| Change in FBF ratio (%) | 0.4 ± 5.4 | −1.0 ± 7.1 | −6.6 ± 6.6 | −10.7 ± 6.6 | 0.390 |
Data are presented as means ± SEM. BP, blood pressure; FBF, forearm blood flow.