Table 3.
Multivariate mixed models examining serum ferritin or ALT changes during chronic transfusion
| Responding/exposure variables | Iron load measure method |
|||
|---|---|---|---|---|
| TIL |
LIC |
|||
| F | P | F | P | |
| Serum ferritin | ||||
| Iron load | 147.79 | < .001 | 15.66 | .006 |
| ALT | 0.37 | .542 | 8.02 | .025 |
| Sex | 0.41 | .523 | 1.32 | .288 |
| Splenectomy | 0.48 | .490 | 0.14 | .715 |
| Weight | 0.51 | .478 | 7.97 | .026 |
| ALT | ||||
| Iron load | 13.62 | < .001 | 10.43 | .012 |
| Sex | 0.03 | .858 | 4.28 | .072 |
| Splenectomy | 0.03 | .859 | 0.26 | .622 |
| Weight | 2.10 | .149 | 0.15 | .709 |
Splenectomy before the start of transfusion therapy, weight at start of transfusion therapy. Model degrees of freedom (numerator/denominator) TIL, 1 of 136; LIC, 1 of 7. When lactose dehydrogenase, white cell count, or hemoglobin S concentration was included in models, these variables did not reach significance (data not shown).