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. 2009 Sep 21;114(21):4675–4686. doi: 10.1182/blood-2009-03-208256

Figure 1.

Figure 1

Levels of TCL1 in CLL correlate with other features of aggressive disease. (A) Increased expression of TCL1 (graded on immunoblots after normalization to β-actin levels) significantly correlated with tumor-cell ZAP70 immunohistochemical expression, unmutated IGHV gene mutational status, surface CD38 levels, and deletions of the chromosome 11q22-23 region. (B) TCL1 levels, using a 4-tier score described in “Methods,” showed a strong positive correlation with the percentage of sIgM+ CLL cells analyzed at the time of TCL1 measurement.