Table 3. Infectivity phenotype of the ruvA mutant T11P01A01 in immunocompetent C3H/HeN and immunodeficient C3H/scid mice is similar to that of the lp28-1− clone 5A8.
Day14 | Day28 | ||||||||||||
No. of cultures positive/total | No. of mice positive/total | No. of cultures positive/total | No. of mice positive/total | ||||||||||
Mouse strain | B. burgdorferi B31 clone | Skin | Joint | Heart | Bladder | All sites | Skin | Joint | Heart | Bladder | All sites | ||
C3H/HeN | 5A18NP1 | 5/5 | 5/5 | 5/5 | 5/5 | 20/20 | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 | 20/20 | 5/5 |
C3H/HeN | ruvA mutant | 0/5 | 3/5 | 0/5 | 0/5 | 3/20 | 3/5 | 2/5 | 2/5 | 2/5 | 1/5 | 7/20 | 3/5 |
C3H/HeN | 5A8 | 0/5 | 3/5 | 0/5 | 0/5 | 3/20 | 3/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/20 | 0/5 |
C3H/scid | 5A18NP1 | 5/5 | 5/5 | 5/5 | 5/5 | 20/20 | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 | 20/20 | 5/5 |
C3H/scid | ruvA mutant | 5/5 | 5/5 | 5/5 | 5/5 | 20/20 | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 | 20/20 | 5/5 |
C3H/scid | 5A8 | 5/5 | 5/5 | 5/5 | 5/5 | 20/20 | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 | 20/20 | 5/5 |