TABLE 2.
Breast cancer mortality of women by use of hormone therapy prior to breast cancer diagnosis for all women and stratified by stage of disease.
|
All Women* (n=12,269) |
Localized (n=7,601) |
Regional (n=3,270) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hormone Therapy | Number of Deaths |
Rate ratio** |
(95%CI) | Multivariate rate ratio**† |
(95%CI) | Number of Deaths |
Multivariate rate ratio**† |
(95%CI) | Number of Deaths |
Multivariate rate ratio**† |
(95%CI) |
| Never‡ | 1,235 | 1.00 | reference | 1.00 | reference | 362 | 1.00 | reference | 623 | 1.00 | reference |
| Any HT Use | 455 | 0.78 | 0.70-0.88 | 0.87 | 0.78-0.98 | 176 | 1.14 | 0.91-1.38 | 219 | 0.84 | 0.71-1.00 |
| Former HT Use | 168 | 0.86 | 0.73-1.01 | 0.92 | 0.78-1.08 | 62 | 1.05 | 0.80-1.39 | 85 | 0.97 | 0.77-1.23 |
| Current HT Use | 287 | 0.74 | 0.65-0.85 | 0.85 | 0.73-0.98 | 114 | 1.21 | 0.95-1.53 | 134 | 0.76 | 0.62-0.94 |
| Type of Exclusive Treatment | |||||||||||
| Estrogen | 270 | 0.81 | 0.71-0.93 | 0.89 | 0.78-1.02 | 108 | 1.17 | 0.94-1.47 | 131 | 0.90 | 0.74-1.09 |
| EP | 104 | 0.64 | 0.52-0.79 | 0.73 | 0.59-0.91 | 40 | 1.00 | 0.70-1.42 | 49 | 0.67 | 0.49-0.91 |
| Other/Unknown | 81 | 0.91 | 0.72-1.14 | 1.01 | 0.80-1.27 | 28 | 1.20 | 0.81-1.78 | 39 | 0.91 | 0.65-1.27 |
| Former or Current Use by Type of Exclusive Treatment | |||||||||||
| Estrogen, Former | 111 0.81 | 0.67-0.99 | 0.86 | 0.71-1.05 | 47 | 1.12 | 0.83-1.53 | 56 | 0.95 | 0.72-1.26 | |
| Estrogen, Current | 159 0.81 | 0.68-0.96 | 0.91 | 0.77-1.09 | 61 | 1.25 | 0.94-1.67 | 75 | 0.84 | 0.65-1.08 | |
| EP, Former | 20 | 0.90 | 0.58-1.40 | 0.96 | 0.62-1.50 | 5 | 0.78 | 0.32-1.90 | 11 | 0.98 | 0.53-1.80 |
| EP, Current | 84 | 0.59 | 0.47-0.75 | 0.69 | 0.55-0.88 | 35 | 1.08 | 0.74-1.58 | 38 | 0.59 | 0.41-0.84 |
| Duration by Type of Exclusive Treatment | |||||||||||
| Estrogen, < 5 years | 111 | 0.83 | 0.69-1.01 | 0.89 | 0.73-1.08 | 45 | 1.21 | 0.88-1.66 | 54 | 0.86 | 0.64-1.14 |
| Estrogen, ≥ 5 years | 159 | 0.79 | 0.67-0.94 | 0.89 | 0.75-1.06 | 63 | 1.17 | 0.89-1.54 | 77 | 0.91 | 0.71-1.16 |
| EP, < 5 years | 64 | 0.74 | 0.57-0.96 | 0.84 | 0.65-1.09 | 24 | 1.12 | 0.73-1.72 | 31 | 0.72 | 0.49-1.06 |
| EP, ≥ 5 years | 40 | 0.51 | 0.37-0.71 | 0.60 | 0.43-0.84 | 16 | 0.89 | 0.52-1.51 | 18 | 0.56 | 0.34-0.93 |
*
Includes all women with local, regional, and distant disease.
**
Proportional hazards models stratified on state, year of interview, and age at diagnosis.
†
Proportional hazards models adjusted for body mass index, menopausal status, smoking status, mammography, and time from date of diagnosis to interview.
‡
Reference category.