Table 1. Quantitative Trait Loci for splenomegaly, hepatomegaly, red blood cell numbers and reticulocyte percentage, that are significant (p<0.05) and highly significant (p≤0.001) in a genome-wide screen.
Phenotype | Chromosome | Number of marker(s)* | Marker above significance threshold | Significance |
Spleen | 1 | 1 | TB1/1 | p<0.05 |
2 | 5 | TB2/16-TB2/20 | p<0.05 | |
3 | 9 | TB3/3-TB3/10 | p≤0.001 | |
10 | 1 | TB10/6 | p<0.05 | |
Liver | 2 | 4 | TB2/22-TB2/6 | p<0.05 |
2 | 4 | TB2/13-TB2/16 | p<0.05 | |
3 | 9 | TB3/3-TB3/10 | p≤0.001 | |
4 | 3 | TB4/16-TB4/11 | p<0.05 | |
5 | 2 | TB5/2-TB5/1 | p<0.05 | |
6 | 5 | TB6/2-TB6/6 | p<0.05 | |
7 | 2 | TB7/1-Tb7/2 | p<0.05 | |
11 | 2 | TB11/3-TB11/4 | p<0.05 | |
11 | 2 | TB11/19-Tb11/20 | p<0.05 | |
Red blood cells | 10 | 1 | TB10/2 | p<0.05 |
11 | 1 | TB11/5 | p<0.05 | |
Reticulocytes | 2 | 5 | TB2/6-TB2/12 | p<0.05 |
8 | 1 | TB8/5 | p<0.05 | |
11 | 1 | TB11/5 | p<0.05 |
*Number of markers that are significant or highly significant (range of markers is indicated in brackets – for details see http://tinyurl.com/trypmap). Highly significant QTLs are shown in bold.