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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Clin Immunol. 2009 Jun 24;132(3):371–384. doi: 10.1016/j.clim.2009.05.016

Figure 5.

Figure 5

VEGF regulates the expression of specific cathepsins (A, B), MMPs (A, B), and VEGF receptor complex (A) in lung mDC. Sorted lung mDC were subjected to tRNA and following cDNA isolation for PCR (A) as described in Material and Methods with corresponding primer’s set. (A) VEGF expression downregulates VEGFR1 and induces VEGFR2 expression in lung mDC. In addition, it upregulates the expression of both neuropilins. (B) VEGF induces MMP-12 but not cathepsin S upregulation in tg mDC as analyzed by Western blot. Of note, cathepsin S is the most highly expressed cathepsin in WT lung mDC.