Table 1.
Demographics and baseline characteristics
| Treatment group | ||
|---|---|---|
| Severe COPD patients n = 28 |
Healthy subjects* n = 27 |
|
| Male, n (%) | 21 (75) | 11 (41) |
| Age, years | 65 (48-80) | 31 (20-65) |
| BMI, kg/m2 | 26.5 (21-32) | 23.1 (18-29) |
| FEV1, l | 1.10 (0.5-1.9) | 3.8 (2.3-5.9) |
| FEV1, % PN | 37.5 (24-51) | 103.3 (84-131) |
| VC, l | 2.8 (1.2-5.2) | 4.6 (3.5-6.6) |
| FVC, l | 2.7 (1.1-4.9) | - |
| FEV1, % FVC | 42.4 (27-60) | - |
| FEV1, % VC | 41.6 (26-63) | 83.1 (66-103) |
| Median time since diagnosis, years (range) | 8.8 (1-37) | - |
| Median pack-years (range) | 40 (10-64) | - |
| Smoking status | - | |
| Previous, n | 16 | - |
| Habitual, n | 22 | - |
| Inhaled ICS at entry | ||
| n | 18 | - |
| μg/day | 777 (160-1600) | - |
Data are mean (range) unless otherwise indicated. BMI = body mass index; FEV1 = forced expiratory volume in 1 second; FVC = forced vital capacity; ICS = inhaled corticosteroid; PN = predicted normal; VC = vital capacity. * Data not collected in healthy subjects on FVC, FEV1, time since diagnosis (not applicable [NA]), smoking (NA) and ICS (NA) at study entry.