Table 1.
RORB SNPs with Significant Association to Bipolar Disorder.
| SNP | Region | Minor Allele | Major Allele | Case-Control MAF | Case MAF | Control MAF | Case-Control OR | Case-Control P-value | TDT MAF (Founders) | T | U | TDT OR | TDT P-value | Combined OR | Combined P-value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs1157358 | Intron 1 | T | C | 0.137 | 0.218 | 0.091 | 2.802 | 4.5E-05 | 0.167 | 29 | 38 | 0.763 | 0.272 | 1.162 | 0.401 |
| rs7022435 | Intron 1 | A | G | 0.176 | 0.310 | 0.135 | 2.881 | 1.1E-06 | 0.203 | 34 | 51 | 0.667 | 0.065 | 1.150 | 0.373 |
| rs3750420 | Intron 2 | T | C | 0.237 | 0.375 | 0.201 | 2.388 | 7.9E-06 | 0.304 | 65 | 66 | 0.985 | 0.930 | 1.176 | 0.214 |
| rs3903529 | Intron 4 | A | T | 0.229 | 0.357 | 0.205 | 2.154 | 8.2E-05 | 0.247 | 34 | 55 | 0.618 | 0.026 | 1.094 | 0.537 |
MAF = Minor Allele Frequency
OR = Odds Ratio of the minor allele
T = Number of transmitted minor alleles
U = Number of untransmitted minor alleles