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In vitro efficacy of NNRTIs against RT-SHIV and other lentiviruses
| NNRTIs | CC50(μM) | EC50(μM) | ||||
|---|---|---|---|---|---|---|
| HIV-1* | RT-SHIV | SIVmac239 | SIVmac251 | SHIV89.6P | ||
| Efavirenz | 3~45 | < 0.001 | 0.003 | > 5 | > 5 | > 5 |
| Nevirapine | 84~100 | 0.028 | 0.06 | > 100 | > 100 | > 100 |
| UC781 | 51~66 | < 0.005 | 0.003 | > 50 | > 10 | > 20 |
CC50: 50% cytotoxic concentration; EC50: 50% effective concentration.
*NNRTIs showed a strong inhibitory activity to both HIV-1Lai and HIV-1BaL.
