Table 1.
Characteristics of 360 immunosuppressed and immunocompetent patients with symptomatic coccidioidomycosis
| Variable | ICH (N = 62) | Non-ICH (N = 298) | P value | ||
|---|---|---|---|---|---|
| No. (%) | 95% CI | No. (%) | 95% CI | ||
| Patient characteristics | |||||
| Age, y (mean ± SD) | 64.8±13.9 | 56.8±16.2 | <.001 | ||
| Male sex | 39 (63) | 51–75 | 157 (53) | 47–58 | .14 |
| White race | 57 (92) | 85–99 | 238 (80) | 75–84 | .03 |
| Patient medical history | |||||
| Cancer | 33 (53) | 41–66 | 60 (20) | 16–25 | <.001 |
| Cardiovascular disease | 36 (58) | 46–70 | 120 (40) | 35–46 | .01 |
| Tobacco use | 34 (55) | 42–67 | 156 (52) | 47–58 | .72 |
| Diabetes mellitus | 15 (24) | 14–35 | 40 (13) | 10–17 | .03 |
| HIV infection | 4 (6) | 0–13 | 0 (0) | 0 (0) | <.001 |
| Rheumatologic illness | 13 (21) | 11–31 | 20 (7) | 4–10 | <.001 |
| Organ transplantation | 7 (11) | 3–19 | 0 (0) | 0 (0) | <.001 |
| Hematologic malignancy | 14 (23) | 12–33 | 0 (0) | 0 (0) | <.001 |
| Nonhematologic malignancy | 19 (31) | 19–42 | 68 (23) | 18–28 | .3 |
| Coccidioidal illness | |||||
| Lungs only | 39 (63) | 51–75 | 231 (78) | 73–82 | .02 |
| Limited to thoracic cavity | 50 (81) | 71–90 | 267 (90) | 86–93 | .048 |
| Extrathoracic dissemination | 12 (19) | 10–29 | 31 (10) | 7–14 | .048 |
| Confirmed by positive microbiologic or histologic tests | 32 (52) | 39–64 | 80 (27) | 22–32 | <.001 |
CI, confidence interval; ICH, immunocompromised; non-ICH, nonimmunocompromised; HIV, human immunodeficiency virus.