Table 2.
Seropositivity among 62 immunocompromised hosts with serologic confirmation of coccidioidomycosis detected by various serologic tests
| Category of immunosuppression | Type of serologic testing, no. (%) | |||||||
|---|---|---|---|---|---|---|---|---|
| EIA (IgM and IgG) | CF | ID (IgM or IgG or both) | Any test | |||||
| Tested | Positive | Tested | Positive | Tested | Positive | Tested | Positive | |
| Hematologic malignancy (N = 14) | 12 | 4 (33) | 10 | 6 (60) | 6 | 1 (17) | 12 | 8 (67) |
| Cancer and chemotherapy, nonhematologic (N = 19) | 18 | 13 (72) | 18 | 12 (67) | 15 | 9 (60) | 19 | 18 (95) |
| HIV infection (N = 4) | 4 | 1 (25) | 3 | 2 (67) | 3 | 2 (67) | 4 | 3 (75) |
| Organ transplantation (N = 7) | 7 | 5 (71) | 6 | 2 (33) | 3 | 0 (0) | 7 | 5 (71) |
| Rheumatologic illness (N = 13) | 11 | 9 (82) | 10 | 6 (60) | 8 | 4 (50) | 11 | 10 (91) |
| Other ICH illness* (N = 11) | 10 | 9 (90) | 10 | 10 (100) | 8 | 6 (75) | 10 | 10 (100) |
| All patients† | 57 | 38 (67) | 52 | 35 (67) | 40 | 21 (53) | 58 | 49 (84) |
| Healthy patients tested ≤ 1 y after symptom onset (N = 261) | 244 | 212 (87) | 252 | 188 (75) | 248 | 180 (73) | 261 | 247 (95) |
CF, complement fixation; EIA, enzyme immunoassay; ICH, immunocompromised; ID, immunodiffusion; HIV, human immunodeficiency virus.
* Patients with other causes of immunocompromise include 3 inflammatory bowel disease (1 taking infliximab), 2 autoimmune blood dyscrasias (hemolytic anemia and idiopathic thrombocytopenic purpura) taking prednisone, 1 autoimmune polyneuropathy, and 5 taking corticosteroids long-term for sarcoid, cough, other pulmonary diseases (chronic obstructive pulmonary disease, interstitial pulmonary fibrosis, or normal interstitial pneumonia).
† Six patients have 2 immunosuppressive illnesses and are represented in each category.