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Overexpression of catalase targeted to mitochondria delays the onset of AHL and reduces cochlear pathology. (A) ABR hearing thresholds were measured from WT and MCAT mice at 4 and 13 months of age (n = 6–9). (B) OH cell and IH cell loss (%) of cochleae were measured from WT and MCAT mice at 13 months of age (n = 5–6). *Significantly different from WT mice (P < 0.05). Error bars represent SEM.
