Fig. 6.

Supplementation of antioxidants that targets mitochondria delays the onset of AHL and reduces cochlear pathology. (A) ABR hearing thresholds were measured at 8, 16, and 32 kHz in 15-month-old mice fed control diet (CD) or diets supplemented with LA, CQ, or NAC compounds (n = 5–7). (B) SG neuron survival (i.e., SG neuron density) of basal cochlear regions was measured from control, LA, and CQ diet-fed mice at 15 months of age (n = 5). (C) Relative cochlear mRNA expression of Bak and Bax was measured in the cochleae from 15-month-old control, LA, and CQ diet-fed mice (n = 5). *Significantly different from control diet or WT mice (P < 0.05). Error bars represent SEM.