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. 2000 Aug 22;97(18):10203–10208. doi: 10.1073/pnas.170226797

Figure 4.

Figure 4

Gut mucosal permeability to FD4 in everted gut sacs incubated ex vivo. Mice (eight PARP+/+ and eight PARP−/−) were bled over 30 min to a mean BP of 45 mmHg. This BP was then maintained for 45 min, followed by resuscitation with isotonic saline (administered over 10 min) at a volume of 2× the shed blood volume. A segment of ileum was harvested 30 min after the beginning of resuscitation to measure the mucosal-to-serosal passage of FD4. The same experiments were made in five PARP+/+ and five PARP−/− mice exposed to sham shock. Values are shown as means ± SEM. †, P < 0.05 vs. sham mice; *, P < 0.05 PARP−/− vs. PARP+/+ mice.