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. 2008 Aug;4(3):179–192. doi: 10.2174/157340308785160570

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©2008 Bentham Science Publishers Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. (1). — IL-6 induced classical and trans-signaling pathways. Shown is a schematic view of classical IL-6 signaling via the IL-6Rα receptor and gp130 for a representative hepatocyte. IL-6Rα bound to the IL-6 ligand results in complex formation with gp130, activating tyrosine kinase activity, including and culminating in tyrosine phosphorylation of STAT3. The IL-6 trans-signaling pathway is diagrammed at top, using a representative endothelial cell. Circulating IL-6∙IL-6Rα engages with gp130 expressed on cells, enabling activation of the IL-6 signaling pathway in cells lacking IL-6Rα. See text for further details.