Skip to main content
. 2009 Dec 2;4(12):e7880. doi: 10.1371/journal.pone.0007880

Table 1. Vaccination schedule for immunogenicity and efficacy studies in BALB/c mice.

Time of Immunization And Challenge Group 1 Gp63 DNA Group 2 Gp63/PB Group 3 Poly DNA Group 4 Poly/PB Group 5 Poly/Hsp Group 6 Poly/Hsp/PB Control group 1 pcDNA Normal Control group 2 PBS
0 day (1st dose) Gp63/pcDNA (100 µg) (i.m.) Gp63/pcDNA (100 µg) (i.m.) Polytope/pcDNA (100 µg) (i.m.) Polytope/pcDNA (100 µg) (i.m.) Polytope/hsp/pcDNA (100 µg) (i.m.) Polytope/hsp/pcDNA (100 µg) (i.m.) Vector plasmid 100 µg (i.m.) PBS
7th day (2nd dose) Gp63/pcDNA (100 µg) (i.m.) Gp63/pcDNA (100 µg) (i.m.) Polytope/pcDNA (100 µg) (i.m.) Polytope/pcDNA (100 µg) (i.m.) Polytope/hsp/pcDNA (100 µg) (i.m.) Polytope/hsp/pcDNA (100 µg) (i.m.) Vector plasmid 100 µg (i.m.) PBS
14th day (3rd dose) Gp63/pcDNA (100 µg) (i.m.) Gp63/pcDNA (100 µg) (i.m.) Polytope/pcDNA (100 µg) (i.m.) Polytope/pcDNA (100 µg) (i.m.) Polytope/hsp/pcDNA (100 µg) (i.m.) Polytope/hsp/pcDNA (100 µg) (i.m.) Vector plasmid 100 µg (i.m.) PBS
21st day (Booster) Gp63/pcDNA (100 µg) (i.m.) Recombinant Gp63 protein (i.p) Polytope/pcDNA (100 µg) (i.m.) Recombinant Gp63 protein (i.p.) Polytope/hsp/pcDNA (100 µg) (i.m.) Recombinant Gp63 protein (i.p.) Vector plasmid 100 µg (i.m.) PBS
Challenge 35th day (2weeks after booster) 2×107 promastigote (i.v.) 2×107 promastigote (i.v.) 2×107 promastigote (i.v.) 2×107 promastigote (i.v.) 2×107 promastigote (i.v.) 2×107 promastigote (i.v.) 2×107 promastigote (i.v.) 2×107 promastigote (i.v.)