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Antiproliferative effects of sirolimus. 4E-BP1 Eukaryotic initiation factor 4E binding protein; CDK Cyclin-dependent kinase; eIF-4E Eukaryotic initiation factor 4E; FKBP12 FK506 binding protein, 12 kDa; mTOR Mammalian target of rapamycin; PI3K Phosphatidylinositol 3-kinase
