TABLE 2.
BMI in the Rotterdam Study and the ERF study by SIRT1 genotype and longitudinal BMI change in the Rotterdam Study
| Genotype | Rotterdam Study baseline |
Rotterdam Study follow-up |
Rotterdam Study BMI change |
ERF study |
P combined‡ | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAF* | Effect size per allele copy† | P trend | MAF | Effect size per allele copy | P trend | MAF | Effect size per allele copy | P trend | MAF | Effect size per allele copy | P trend | ||
| rs7895833 | 0.20 | −0.190 (0.08) | 0.02 | 0.20 | −0.291 (0.12) | 0.02 | 0.20 | −0.126 (0.05) | 0.01 | 0.23 | −0.350 (0.16) | 0.03 | 0.002 |
| rs1467568 | 0.37 | −0.149 (0.07) | 0.04 | 0.37 | −0.238 (0.10) | 0.02 | 0.37 | −0.075 (0.04) | 0.08 | 0.41 | −0.372 (0.14) | 0.008 | 0.002 |
| rs497849 | 0.22 | +0.030 (0.08) | 0.70 | 0.22 | −0.054 (0.11) | 0.62 | 0.22 | −0.020 (0.05) | 0.69 | — | |||
| Haplotype 1 | 0.41 | +0.130 (0.07) | 0.07 | 0.41 | +0.273 (0.10) | 0.008 | 0.41 | +0.070 (0.05) | 0.11 | — | |||
Analyses adjusted for age, sex, and genomic control and, in ERF, also for family structure.
*Minor allele rs7895833; G, rs1467568; A, rs497849.
†Effect size is difference in BMI (kg/m2) (SE) or difference in BMI change per allele.
‡P combined analysis for Rotterdam Study baseline and the ERF study. MAF, minor allele frequency.