Table 2.

Linear regression of muscle FGF-21 expression adjusted by GAPDH and plasma FGF-21 for men and women

	Muscle FGF-21 mRNA					Plasma FGF-21
	β Coefficients	95% CI		R2	P	β Coefficients	95% CI		R2	P
		Low	High				Low	High
Men (n = 122 for muscle and n = 142 for plasma)
Body weight (kg)	0.002	−0.013	0.017	0.095	0.75	<0.001	−0.009	0.009	0.021	0.97
Waist-to-hip ratio	−0.187	−1.916	1.543	0.094	0.83	0.097	−1.034	1.228	0.021	0.87
Waist circumference (cm)	−0.002	−0.023	0.019	0.094	0.85	0.003	−0.010	0.016	0.023	0.66
Glucose (mmol/l)*	0.309	−0.273	0.891	0.102	0.30	0.446	0.055	0.838	0.056	0.03
Insulin (pmol/l)*	0.465	0.100	0.829	0.140	0.01	0.194	−0.048	0.437	0.039	0.12
A1C (%)*	0.428	−0.799	1.654	0.097	0.49	0.646	−0.134	1.425	0.040	0.10
HOMA score*	0.393	0.058	0.729	0.133	0.02	0.238	0.015	0.461	0.052	0.04
HDL cholesterol*	−0.864	−1.600	−0.128	0.134	0.02	−0.496	−1.007	0.015	0.047	0.06
FGF-21, plasma (pg/ml)*	0.139	−0.102	0.380	0.104	0.26
Women (n = 48 for muscle and n = 56 for plasma)
Body weight (kg)	<0.001	−0.024	0.024	0.067	1.00	0.003	−0.007	0.013	0.097	0.59
Waist-to-hip ratio	0.568	−1.558	2.694	0.073	0.59	−0.626	−1.542	0.290	0.124	0.18
Waist circumference (cm)	0.010	−0.014	0.034	0.082	0.41	−0.009	−0.019	0.001	0.147	0.07
Glucose (mmol/l)*	0.394	−1.019	1.807	0.074	0.58	0.114	−0.520	0.749	0.095	0.72
Insulin (pmol/l)*	−0.253	−0.914	0.408	0.080	0.45	0.010	−0.285	0.305	0.092	0.95
A1C (%)*	0.695	−2.606	3.996	0.071	0.67	0.321	−1.165	1.807	0.096	0.67
HOMA score*	−0.199	−0.842	0.443	0.076	0.54	0.008	−0.278	0.295	0.092	0.96
HDL cholesterol*	0.319	−1.045	1.682	0.072	0.64	−0.730	1.294	−0.166	0.197	0.01
FGF-21, plasma (pg/ml)*	−0.534	−1.190	0.121	0.112	0.11

Regressions adjusted by BMI and age.

*Log-transformed before analysis.