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. 2009 Sep 9;58(12):2946–2953. doi: 10.2337/db09-0228

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© 2009 American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — Hypothesized effect of GCK rs1799884 and G6PC2 rs560887 genotype combinations on ATP production and insulin secretion in pancreatic β-cells. Upper portion of the figure shows the glucose-cycling step and the effect of specific alleles in GCK and G6PC2 on activity of each enzyme: thick arrow depicts increased activity, thin arrow depicts reduced activity. Lower portion shows the specific genotype combinations and the hypothesized effect on ATP production and subsequent insulin secretion.