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. 2009 Sep 9;58(12):2946–2953. doi: 10.2337/db09-0228

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© 2009 American Diabetes Association

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FIG. 2. — The 30′ Δinsulin and fasting glucose stratified by GCK rs1799884 and G6PC2 rs560887 genotypes. A: Age- and sex-adjusted 30′ Δinsulin (means ± SE) stratified by GCK rs1799884 and G6PC2 rs560887 genotype combination. Genotype groups are ordered by hypothesized effect on glucose cycling in the pancreatic β-cell (see text for details). Dominant genetic models are assumed for both loci. 30′ Δinsulin changed linearly (P = 0.0016) with genotype group. B: Age- and sex-adjusted fasting plasma glucose (means ± SE) stratified by genotype. Details are as described for top panel. Fasting glucose was not linearly related to genotype group (P = 0.191).