TABLE 2.

Univariate tests of associations between genetic variants and fasting glucose and measures of insulin secretion

	GCK (rs1799884)			G6PC2 (rs560887)
	GG (n = 405)	GA or AA (n = 207)	Uncorrected P*	GG (n = 458)	GA or AA (n = 165)	Uncorrected P*
Fasting glucose (mM)	5.13 ± 0.52	5.22 ± 0.59	0.052	5.19 ± 0.52	5.08 ± 0.61	0.015
Fasting insulin (pM)	63.2 ± 49.7	57.5 ± 47.3	0.412	60.5 ± 45.3	63.0 ± 57.0	0.833
30′ Δinsulin (pM)	489 ± 338	447 ± 314	0.119	488 ± 339	427 ± 300	0.004
AIR (pM × 10 min)	6,197 ± 6,238	5,721 ± 4,258	0.770	6,196 ± 5,673	5,650 ± 5,485	0.088

Data are unadjusted means ± SD unless otherwise indicated.

*Age- and sex-adjusted P value not corrected for multiple testing.