TABLE 3.
Univariate tests of associations between genetic variants and additional type 2 diabetes–related quantitative traits
|
GCK (rs1799884) |
G6PC2 (rs560887) |
|||||
|---|---|---|---|---|---|---|
| GG (n = 405) | GA or AA (n = 207) | Uncorrected P* | GG (n = 458) | GA or AA (n = 165) | Uncorrected P* | |
| BMI (kg/m2) | 29.6 ± 6.4 | 28.7 ± 5.6 | 0.150 | 29.7 ± 6.2 | 28.3 ± 5.7 | 0.012 |
| Body fat (%) | 32.2 ± 8.6 | 31.8 ± 8.3 | 0.121 | 32.5 ± 8.5 | 31.4 ± 8.4 | 0.007 |
| 2-h glucose (mM) | 7.39 ± 2.24 | 7.40 ± 2.07 | 0.477 | 7.38 ± 2.08 | 7.45 ± 2.43 | 0.805 |
| 2-h insulin (pM) | 505 ± 416 | 485 ± 374 | 0.764 | 502 ± 409 | 488 ± 377 | 0.871 |
| SG (×10−2 min−1) | 1.78 ± 0.71 | 1.73 ± 0.66 | 0.340 | 1.78 ± 0.67 | 1.73 ± 0.74 | 0.218 |
| SI (×10−3 min−1 per pM) | 3.02 ± 1.78 | 3.00 ± 1.48 | 0.944 | 2.96 ± 1.68 | 3.12 ± 1.66 | 0.469 |
Data are unadjusted means ± SD unless otherwise indicated.
*Age- and sex-adjusted P value not corrected for multiple testing.