TABLE 1.

Accuracy of 64-slice multidetector computed tomography for the assessment of coronary artery stenosis compared with catheter-based coronary angiography (CCA)

Reference	Patients, n	Patient population	Mean age, years	Men, %	Prevalence of CAD, %	Vessel diameter analyzed	Assessability, %	Sensitivity, %	Specificity, %	NPV, %	PPV, %	Diagnostic accuracy, %	Positive likelihood ratio	Negative likelihood ratio
Ong et al (7)	134	Scheduled angiography	55	73	73	≥1.5 mm	90	82	96	96	79	93	20.5	0.2
Meijboom et al (8)	104	Suspected CAD	59	72	85	N/A	100	92	91	99	60	91	10.2	0.1
Ropers et al (9)	84	Scheduled angiography	58	62	32	≥1.5 mm	96	93	97	100	56	97	31.0	0.1
Oncel et al (10)	80	Suspected CAD	56	76	77	≥2 mm	100	96	98	99	91	98	48	0
Nikolaou et al (11)	72	Suspected CAD	64	82	54	≥1.5 or2 mm	90	82	95	97	72	93	27.3	0.2
Raff et al (12)*	70	Suspected CAD	59	73	54	All vessels	100	86	95	98	66	94	17.2	0.1
Ehara et al (13)†	69	Suspected CAD	69	75	88	All vessels	92	90	94	95	89	93	15.0	0.1
Leschka et al (14)‡	67	Suspected CAD	62	74	70	≥1.5 mm	100	94	97	99	87	97	31.3	0.1
Schuijf et al (15)	61	Scheduled angiography	60	77	52	N/A	99	85	98	99	82	93	42.5	0.3
Leber et al (16)	55	Scheduled angiography	N/A	N/A	56	All vessels	100	77	97	95	85	94	25.7	0.2
Mollet et al (17)	52	Scheduled angiography	59	65	90	≥1.5 or	100	99	95	99	76	96	19.8	0.0
Mühlenbruch et al (18)§	51	Suspected CAD	59	76	88	N/A	91	87	95	98	75	94	17.4	0.1
Plass et al (19)	50	Scheduled angiography	66	78	80	≥1.5 mm	92	93	97	98	91	96	31	0.1
Scheffel et al (20)	38	Scheduled angiography	50	76	76	≥1.0 mm	98	93	99	99	91	99	93	0.1
Pugliese et al (21)*	21	Stable angina	61	100	71	All vessels	100	99	96	99	78	96	24.8	0.0
Total	1008						97	89	96	98	79	95	22.3	0.1

All studies were blinded.

^*Quantitative CCA was not performed. Evaluation of coronary artery stenosis was made by visual analysis of CCA;

^†57% of patients had at least 1 stent;

^‡Beta-blockers were not administered for heart rate reduction;

^§Defined coronary artery stenosis as >70% luminal narrowing of vessel. Coronary artery stenosis was defined as >50% luminal narrowing of vessel in all other studies. CAD Coronary artery disease; N/A Not available; NPV Negative predictive value; PPV Positive predictive value