TABLE 2.
Accuracy of 16-slice multidetector computed tomography for the assessment of coronary artery stenosis compared with catheter-based coronary angiography (CCA)
| Reference | Patients, n | Patient population | Mean age, years | Men, % | Prevalence of CAD, % | Vessel diameter analyzed | Assessability, % | Sensitivity, % | Specificity, % | NPV, % | PPV, % | Diagnostic accuracy, % | Positive likelihood ratio | Negative likelihood ratio |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Garcia et al (22) | 238 | Scheduled angiography | 60 | 68 | 100 | ≥1.5 mm | 71 | 85 | 91 | 99 | 36 | 91 | 67 | 0.3 |
| Mollet et al (23) | 128 | Stable angina | 59 | 88 | 83 | ≥2.0 mm | 100 | 92 | 95 | 98 | 79 | 95 | 18.4 | 0.1 |
| Hoffmann et al (24) | 103 | Scheduled angiography | 61.5 | 69 | 56 | ≥1.5 mm | 93 | 95 | 99 | 99 | 87 | 98 | 95.0 | 0.1 |
| Ropers et al (25) | 77 | Scheduled angiography | 58 | 65 | 53 | ≥1.5 mm | 88 | 91 | 93 | 98 | 78 | 93 | 13.0 | 0.1 |
| Kuettner et al (26) | 72 | Scheduled angiography | 64 | 58 | 50 | N/A | 100 | 82 | 98 | 97 | 87 | 96 | 41.0 | 0.2 |
| Ghersin et al (27)*† | 66 | Acute angina | 57 | 79 | N/A | ≥2.0 mm | 97 | 80 | 89 | 97 | 52 | 87 | 7.3 | 0.2 |
| Martuscelli et al (28) | 64 | Scheduled angiography | 58 | 92 | 67 | ≥1.5 mm | 84 | 89 | 98 | 98 | 90 | 97 | 44.5 | 0.1 |
| Nikolaou et al (29) | 64 | Suspected CAD | 60 | 53 | 83 | N/A | 92 | 80 | 99 | 99 | 57 | 99 | 80 | 0.2 |
| Kuettner et al (30) | 60 | Scheduled angiography | 58 | 73 | 60 | N/A | 100 | 70 | 97 | 97 | 70 | 95 | 23.3 | 0.3 |
| Nieman et al (31) | 59 | Scheduled angiography | 58 | 90 | 86 | ≥2.0 mm | 100 | 95 | 86 | 97 | 80 | 90 | 6.8 | 0.1 |
| Kefer et al (32) | 52 | Scheduled angiography | 50 | 64 | 80 | ≥1.5 mm | 75 | 67 | 99 | 98 | 88 | 97 | 67 | 0.3 |
| Mollet et al (33) | 51 | Typical/atypical angina | 59 | 73 | 63 | ≥2.0 mm | 100 | 95 | 98 | 99 | 87 | 98 | 47.5 | 0.1 |
| Achenbach et al (34) | 50 | Scheduled angiography | 62 | 50 | 54 | ≥1.5 mm | 96 | 94 | 96 | 99 | 68 | 96 | 23.5 | 0.1 |
| Cademartiri et al (35) | 40 | Suspected CAD | 59 | 90 | N/A | ≥2.0 mm | 100 | 96 | 96 | 99 | 86 | 96 | 24.0 | 0.0 |
| Manghat et al (36) | 36 | Scheduled angiography | 71 | 68 | 42 | N/A | 92 | 82 | 95 | 98 | 58 | 94 | 16.4 | 0.2 |
| Hoffmann et al (37) | 33 | Suspected CAD | 57 | 82 | 67 | N/A | 82 | 70 | 94 | 97 | 58 | 92 | 11.7 | 0.3 |
| Total | 1193 | 92 | 88 | 96 | 98 | 73 | 95 | 22.0 | 0.1 |
All studies were blinded. Coronary artery stenosis was defined as >50% luminal narrowing of vessel.
*
Quantitative CCA was not performed. Evaluation of coronary artery stenosis was made based on visual analysis of CCA;
†
Beta-blockers were not administered for heart rate reduction. CAD Coronary artery disease; N/A Not available; NPV Negative predictive value; PPV Positive predictive value