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. 2009 Sep 10;86(6):1385–1392. doi: 10.1189/jlb.0309183

Figure 1.

Figure 1.

Effects of PARP-1 gene deletion on airway inflammatory cell recruitment in response to intratracheal administration of LPS or TNF in mice. C57BL/6 WT or PARP-1−/− mice were subjected to a single intratracheal administration of LPS (50 μg/mouse) or TNF (100 ng/mouse) in 50 μl saline. Twenty-four hours after treatment, BALF were collected and centrifuged; cells were then differentially stained and visualized by light microscopy, followed by a count of total cells (A), macrophages (B), and neutrophils (C). Data are given as means ± sd of values obtained from at least four mice/group. *, Difference from respective untreated control mice, P < 0.01; #, difference from LPS- or TNF-treated WT mice, P < 0.01. (D) A sample of H&E-stained cells collected from BALF of LPS- or TNF-treated WT or PARP-1−/− mice.