Table 1.
A list of predicted PID genes whose association with immunological disorders has been reported recently
| Gene symbol | Molecule class | Immunological disorder(s) | Reference(s) |
|---|---|---|---|
| ITGAM | Cell surface receptor | Systemic lupus erythematosus | Harley et al., Nat. Genet., 2008 (PubMed ID: 18204446);55 Nath et al., Nature Genetics, 2008 (PubMed ID: 18204448)56 |
| BANK1 | Chaperone | Systemic lupus erythematosus | Kozyrev et al., Nat. Genet., 2008 (PubMed ID: 18204447)57 |
| MST1 | Growth factor | Inflammatory bowel disease | Goyette et al., Mucosal Immunol., 2008 (PubMed ID: 19079170)58 |
| CYLD | Ubiquitin–proteasome system protein | Crohn's disease | Johnson and O'Donnell et al., BMC Med. Genet., 2009 (PubMed ID: 19161620)59 |
| PTPN2 | Tyrosine phosphatase | Crohn's disease | Wellcome Trust Case Control Consortium, 2007;60 Todd et al., Nat. Genet., 2007 (PubMed ID: 17554260)61 |
| PTPN22 | Tyrosine phosphatase | Systemic lupus erythematosus | Wellcome Trust Case Control Consortium, 2007;60 Harley et al., Nat. Genet., 2008 (PubMed ID: 18204446)55 |
| TNFAIP3 | Transcription regulatory protein | Rheumatoid arthritis | Plenge et al., Nat. Genet., 2007 (PubMed ID: 17982456)62 |
| STAT4 | Transcription factor | Systemic lupus erythematosus | Remmers et al., N Engl J Med., 2007 (PubMed ID: 17804842)63 |
| TNFSF4 | Ligand | Systemic lupus erythematosus | Graham et al., Nat. Genet., 2008 (PubMed ID: 18059267)64 |
| CTLA4 | Adhesion molecule | Autoimmune thyroid diseases | Ueda et al., Nature, 2003 (PubMed ID: 12724780);65 Ikegami et al., J. Clin. Endocrinol. Metab., 2006 (PubMed ID: 16352685)66 |