Table 1.

Background characteristics of the full economic evaluations

	Deuson et al. [17]	San Sebastian et al. [18]	Weaver et al. [19]
Area studied	Philadelphia, USA	Low-Napo area in Napo province, covering 300 km of the Napo river	Seattle, USA
Timing of the study	October 1994 - February 1996	1993-1995	October- November 1996
Type of intervention	Promotion prior to a catch-up campaign1	Campaign	Promotion
Type of LHW/role of LHW	Staff of community-based organisation	CHWs*	Senior volunteers, i.e. older people
Training	Unstated	3-year training in preventive medicine, including immunisation, and curative activities	Received training about the pneumococcal and influenza vaccines and received technical support from the project coordinator.
Comparator(s)	(Implicitly) Doing nothing	Centrally planned strategy (District Hospital strategy) of immunizing children <1 year	(Implicitly) Doing nothing
Study type	CEA & CUA	CEA	CEA
Vaccines delivered	Hepatitis B	Routine childhood vaccines	Pneumococcal and influenza vaccines
Age group(s) targeted	2-13 year-olds	0-5 years-old	65 years +
Perspective(s)	Societal	Societal	Societal
$ per child vaccinated	Costs per child, per dose, and per completed series were $64, $119, and $537, respectively	$32 per FVC	Not stated
CE results	The cost per discounted year of life saved was $11,525 and the benefit-cost ratio was 4.44:1	CHW intervention dominated the District Hospital comparison	Intervention cost $35,486/QALY gained for the combined outreach initiative, $53,547/QALY for the pneumococcal vaccine and $130,908/QALY for the influenza vaccine. For seniors who had never received a vaccine, the combined outreach initiative cost $11,771/QALY gained, $38,030/QALY for the pneumococcal vaccine, and $22,431/QALY for the influenza vaccine.
Funded by	Centers for Disease Control (CDC), USA	Medicus Mundi Andalucia, Spain	CDC

* Local indigenous organization started a PHC programme in 25 communities with training of CHWs. Each community has two CHWs with 3 year training in preventive medicine, including immunisation and curative activities. CHWs are literate and elected by their own community and receive no financial reward.

¹ Catch-up campaign: targeted efforts to vaccinate individuals that did not receive the vaccine that they would otherwise have received through routine immunisation

Campaign: targeted efforts of vaccinating a group of and/or a pre-determined number of individuals for vaccination