Table 2.
Frequency of chromosomal aberrations in bone marrow cells from mice treated by SAA
| Treatment | Chromosomal aberration | Aberrations per 100 cells | ||||
|---|---|---|---|---|---|---|
| G' | G" | B' | B" | Total | ||
| Control (water) | 14 | 0 | 5 | 0 | 19 | 1.9 ± 0.88 |
| CTX (40 mg kg-1) | 47 | 4 | 258 | 2 | 311 | 31.1 ± 1.56** |
| SAA (g kg-1) | ||||||
| 2.5 | 12 | 0 | 7 | 0 | 19 | 1.91 ± 1.37 |
| 5.0 | 14 | 1 | 8 | 0 | 23 | 2.3 ± 0.67 |
| 10.0# | 10 | 0 | 7 | 0 | 17 | 1.7 ± 0.95 |
The mice were sacrificed 6 h after treatment with colchicine. One hundred cells were analyzed per animal for a total of 1000 cells per treatment. CTX = cyclophosphamide; G' = chromatid gap; G" = chromosome gap; B' = chromatid break; B" = chromosome break.
**Significantly different vs the negative control (P < 0.01, χ2 test).
# The highest SAA dose was nearly the maximum tolerated dose.