Table 1.

Summary of 4 Randomized, Double-Blind, Placebo-Controlled Studies of Duloxetine for the Treatment of Fibromyalgia

Study	Treatment Duration	Dose	Duloxetine (n)	Placebo (n)	Primary Efficacy Measures
118	12 wk	60 mg bid	104	103	FIQ total score
					FIQ pain score
219	12 wk	60 mg qd	118	120	BPI 24-h average pain score
		60 mg bid	116
320	28 wk	20 mg qd	79	144	BPI 24-h average pain score
		60 mg qd	150		PGI-I score
		120 mg qd	147
421	28 wk	60/120 mg qd	162	168	BPI 24-h average pain score
					PGI-I score

Abbreviations: bid = twice daily, BPI = Brief Pain Inventory FIQ = Fibromyalgia Impact Questionnaire, PGI-I = Patient Global Impressions-Improvement scale, qd = once daily.