Table 6.
Baseline and Endpoint Changes in BPI 24-Hour Pain Measures in Demographic Subgroups for Age, Gender, and Ethnicity
| Duloxetine |
Placebo |
Treatment-by-Subgroup Interaction P Value a | ||||||
| Subgroup | n | Baseline, Mean (SD) | Least Squares Change, Mean (SE) | n | Baseline, Mean (SD) | Least Squares Change, Mean (SE) | Duloxetine vs Placebo P Value | |
| Womenb | 500 | 6.46 (1.6) | −1.74 (0.1) | 382 | 6.41 (1.6) | −1.10 (0.1) | < .001 | .320 |
| Men | 44 | 6.07 (1.4) | −1.28 (0.4) | 26 | 6.27 (1.6) | −1.25 (0.5) | .969 | |
| < 65 y | 707 | 6.39 (1.5) | −1.90 (0.1) | 483 | 6.46 (1.6) | −1.11 (0.1) | < .001 | .362 |
| ≥ 65 y | 67 | 6.60 (1.9) | −1.92 (0.3) | 43 | 6.02 (1.8) | −1.50 (0.4) | .374 | |
| White | 683 | 6.33 (1.5) | −1.92 (0.1) | 455 | 6.32 (1.5) | −1.12 (0.1) | < .001 | .180 |
| Other | 91 | 6.97 (1.8) | −1.70 (0.3) | 71 | 7.04 (1.8) | −1.37 (0.3) | .386 | |
a
Treatment-by-subgroup interaction is significant at P ≤ .10.
b
Study 2 was not included in the subgroup analysis by sex, because only female patients were enrolled.
Abbreviation: BPI = Brief Pain Inventory.