Fig. 5.

numb regulates the subcellular localization of Spdo. Spdo localization (green) in ectodermal cells of otherwise wild-type (A) or numb mutant (B) embryos. (A) Spdo exhibits predominately diffuse and punctate localization in ectodermal cells of wild-type embryos. (B) Spdo exhibits increased localization to the cell membrane of ectodermal cells in numb mutant embryos. Each panel shows a single z-section of a stage 12 embryo taken at similar apical basal positions; both embryos were processed in parallel and imaged on a Leica SPII confocal microscope using identical parameters. Spdo misexpression mediated by scabrous-GAL4. Anterior, left.