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. 2009 Dec 15;136(24):4165–4176. doi: 10.1242/dev.044263

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Fig. 3. — LanB1 is required for proper localisation of Collagen IV at basement membranes. (A-F) Dorsal views of stage 16 embryos (A,B). Lateral views of stage 15 (C,D) and 16 (E,F) embryos. (A,D) In wild-type embryos Collagen IV (red) is found at BMs surrounding the brain (arrow) and midgut (magnification in the white box). (B) This localisation is severely disrupted in LanB1^def embryos. (C) In addition, Collagen IV localisation in the ventral nerve cord channels of a stage 15 embryo (arrow) is lost in LanB1^def embryos (D, arrow). (E,F) In stage 16 embryos, the ventral nerve cord, visualised with anti-FasII antibody (red), fails to condense properly in LanB1^def mutants. White horizontal bars indicate the length of CNS condensation.