Table 3.
Association of Hypermethylation in p16 and FHIT Genes in Association with Premenopausal and Postmenopausal Status in Breast Cancer Patients.
| Promoters | Premenopausal | Postmenopausal | P | OR (95% CI) |
| p16 unmethylated | 71 | 168 | 1.0 (reference) | |
| p16 methylated | 46 | 66 | .039 | 1.71* (1.1–2.89) |
| FHIT unmethylated | 64 | 158 | 1.0 (reference) | |
| FHIT methylated | 53 | 76 | .025 | 1.79* (1.2–2.98) |
Odds ratios and 95% CI were estimated with unconditional logistic model adjusted for various confounding factors such as age at the time of diagnosis and smoking habits
*
P < .05.