Figure 4.
SWAP-70 knockdown alters glioma cell morphology. (A) T98 and SNB19 glioma cells were treated with either nontargeting or SWAP-70 siRNA and SWAP-70 expression was assessed 72 hours after transfection. Greater than 80% knockdown was observed in both cell lines. (B) The morphology of T98 (left panels) and SNB19 (right panels) glioma cells after SWAP-70 siRNA transfection tended to be rounder and smaller and had a reduced number of membrane ruffles compared with nontargeting siRNA controls (left panels). si-NT indicates non-targeting siRNA; si-SW70, siRNA-SWAP-70.