Figure 1. Relationship between the impact of positive design on the stability of different lattice folds and their respective average contact-frequencies.
The values of a measure of the effect of positive design of stability, <D(i,j)>short, for the 1081 different folds of 25 residue-long sequences on a 5×5 lattice are plotted against their respective average contact-frequencies, . A linear correlation is observed with r = −0.6082 and a P-value<0.0001.