Experimental studies: Statistical significance

Subject studies	Vitro	Vivo
Mice	Curcumin was a A-beta40 aggregation inhibitor prevented A-beta42 oligomer formation and toxicity between 0.1-1.0 microM.	Given to aged Tg2576 mice with advanced amyloid accumulation, curcumin reduced amyloid levels and plaque burden reduction in plaque burden (p > 0.0001)[46]
	These changes were statistically significant p value (p > 0.001)[26]
Rat	The middle-aged rats (n = 10) that were fed with various diets were evaluated for spatial memory deficits in a standard Morris water maze, showed that A_infused rats fed with curcumin (500 ppm) showed reduced path length and latency in finding the hidden platform and increase in spatial memory. (p < 0.001). The synotopsin loss was signi. cantly reduced in A-infused rats fed curcumin (p < 0.05) and Curcumin and ibuprofen reduced microglial area in both cortical layers (p < 0.05)	(1) Rats injected intraperitoneally with lead acetate (20 mg/kg) in the presence and absence of curcumin (30 mg/kg) were compared. Lead-induced damage to neurons signi. cantly reduced (p < 0.001) when studied microscopically to determine the extent of lead-induced damage to the cells in the hippocampus.[34] (2) 500 ppm of Curcumin in the diet for 4 weeks reduced the oxidative damage in rats (n = 8/group) with mild fluid percussion brain injury. Curcumin supplementation counteracted the impairment in cognition caused by traumatic brain injury with (p < 0.05).[47]
Planaria	Curcumin improved the memory curves in planaria with correlation coef. cient of 0.97.[48]