Table 3.

Laboratory measurements over time

Laboratory parameter	Sevelamer carbonate powder TID (N = 31)	Sevelamer hydrochloride tablets TID (N = 28)	P-value*
Bicarbonate (mmol/L) (mEq/L)			0.001
Baseline	18.0 ± 3.1 (18.0 ± 3.1)	17.8 ± 3.2 (17.8 ± 3.2)
Final	20.2 ± 2.8 (20.2 ± 2.8)	18.0 ± 3.1 (18.0 ± 3.1)
Change	2.7 ± 3.7 (2.7 ± 3.7)	0.1 ± 3.3 (0.1 ± 3.3)
P-value*	0.001	0.791
Calcium (mmol/L) (mg/dL)			0.665
Baseline	2.3 ± 0.2 (9.1 ± 0.9)	2.3 ± 0.2 (9.1 ± 1.0)
Final	2.3 ± 0.2 (9.1 ± 0.8)	2.3 ± 0.2 (9.1 ± 0.9)
Change	−0.0 ± 0.1 (−0.1 ± 0.5)	−0.0 ± 0.2 (−0.0 ± 0.9)
P-value*	0.173	0.734
iPTH (pmol/L) (pg/mL)a			0.404
Baseline	31 (291)	33 (310)
Final	41 (390)	43 (408)
Change	3 (30)	4 (42)
P-value*	0.272	0.019

^aSerum iPTH presented as median.

^*Wilcoxon signed-rank test used to compare change from baseline between treatment regimens and to assess change from baseline within each treatment.

The number of observations varies in the statistics shown.