Figure 1. Combination of PDGF and VEGF receptor kinase antagonists lowers tumor IFP.

Mice with KAT-4 tumors grown subcutaneously were treated with vehicle, STI571, PTK/ZK, or with combinations of STI571 and PTK/ZK. The IFP of the tumors were measured by the wick-in-needle technique. Data are presented as means +/− SEM. Statistically significant differences (p<0.05) compared to vehicle and long term combination treatment (*), and to all groups (#) are indicated.