Table 1. Extracellular volume (ECV), plasma volume (PV) and total tissue water (TTW) measured in the animals treated with either PBS, PTK/ZK, STI571 as well as short and long term combination treatment.

	Tumor			Skin
	TTW (mL/g dry weight)	PV (mL/g dry weight)	ECV (mL/g dry weight)	TTW (mL/g dry weight)	PV (mL/g dry weight)	ECV (mL/g dry weight)
PBS (n = 10)	4.756±0.668	0.041±0.019	1.612±0.451	1.944±0.406	0.008±0.005	1.357±0.430
STI571 4d (n = 7)	5.162±0.208	0.047±0.020	2.187±0.321 *	2.804±1.404	0.017±0.006§	2.053±0.851§
PTK/ZK 4d (n = 8)	4.977±0.538	0.052±0.033	1.533±0.311	2.573±0.744	0.018±0.012	1.614±0.422
PTK/ZK 2d/STI571 4d (n = 7)	4.658±0.876	0.156±0.250	1.515±0.481	3.122±1.279	0.110±0.106 *	2.399±1.097 *
PTK/ZK 4d/STI571 4d (n = 6)	5.187±0.789	0.046±0.026	2.140±0.587	2.348±0.672	0.016±0.006	1.704±0.527

All results are presented as mean and S.E.M. Analysis of statistical significance was evaluated with 1-way ANOVA followed by the post-hoc Dunn's test.

^* p<0.05 compared to PBS treatment.

^§ p<0.05 compared to PBS treatment when removing the highest outlying data point in PTK/ZK 2d/STI571 4d treatment group.