Table II -.
Genome-wide association studies.
| Study | Population | SNPs evaluated (n) | Study sample (number of participants) | SNPs/chromosomal loci associated | Phenotype |
|---|---|---|---|---|---|
| O’Donnel CJ et al. (21) | American | 100,000 | 1,345 subjects from 310 families | -rs1376877(2q33) | IMT |
| O’Donnel CJ et al. (21) | American | 100,000 | 1,345 subjects from 310 families | -rs4814615(20p12) | IMT |
| O’Donnel CJ et al. (21) | American | 100,000 | 1,345 subjects from 310 families | -9p21 | CHD |
| Scuteri A et al. (22) | American, European | 362,129 | 4,741 subjects from Sardinia; 3,467 subjects from the GenNet Study | -16q12 | Obesity-related trait |
| Florez CJ et al. (23) | American | 66,543 | 1,087 Framingham Heart Study Family members | -rs2863389 (3q26) -rs7935082 (11q12) -rs952635 (1p31) |
Diabetes |
| Larson MG et al. (24) | American | 70,987 | 1,345 Framingham Heart Study participants from 310 families | -9p21 | CVD |
| Samani NJ et al. (25) | European Whites | 500,000 | 1,988 CHD patients and 3,004 from the WTCCC Study/875 CHD patients and 1644 controls from the German MI Family Study | -9p21.3 -6q25.1 -2q36.3 |
CAD |