Table II - .
Genetic association studies on antihypertensive response.
| Gene | SNP | Outcome | Study | Findings | Similar | Dissimilar |
|---|---|---|---|---|---|---|
| Diuretics | ||||||
| ADD1 | G460W | Blood pressure | Cusi et al. (54) | W allele carriers respond better | (55, 56) | (57-60) |
| MI/stroke | Psaty et al. (61) | W allele carriers respond better | (57, 62) | |||
| ACE | I/D | Blood pressure | Sciarrone et al. (56) | Better response in II carriers | (123)** | (123)** |
| AGT | A(-6)G* | Blood pressure | Frazier et al. (64) | -6A greater response (in AfrA women) | (59, 65) | |
| AGTR1 | A1166C | Blood pressure | Frazier et al. (64) | A allele better response (in AfrA women) | (59, 65) | |
| GNB3 | C825T | Blood pressure | Turner et al. (66) | Better response TT compared to CC | (59) | |
| Beta Blockers | ||||||
| ADRB1 | R389G | Blood pressure | Sofowora et al. (71) | AA greater response than GG | (70, 72, 73) | (69, 74, 75) |
| AGT | A(-6)G* | Blood pressure | Kurland et al. (76) | -6A allele greater response | (77, 78) | |
| ACE inhibitors | ||||||
| ACE | I/D | Blood pressure | Hingorani et al. (80) | No effect | (59, 63, 78, 79, 124- 133)*** | (133-137) (II > DD) (138-140) (DD>II) |
| AGT | M235T | Blood pressure | Hingorani et al. (80) | MT and TT greater response than MM | (59, 60, | |
| Clinical event | Bis et al. (143) | TT less risk of stroke (not MI) | (62) | |||
| Angiotensin2 type 1 receptor antagonists | ||||||
| ACE | I/D | Blood pressure | Kurland et al. (77) | II carriers greater response | (82, 83) | |
| CYP11B2 | C-344T | Blood pressure | Kurland et al. (81) | TT carriers greater response | (83) | |
| AGTR1 | A1166C | Blood pressure | Miller et al. (144) | C carriers greater response | (77, 82) |
*
In linkage disequilibrium with M235T polymorphism.
**
Similar result for women, men more benefit with DD genotype.
***
O’Toole et al. (133): Lisonopril no association, captopril associated. AfrA = African American descent.