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The biosynthetic secretory pathway for CT. ProCT (ProCalcitonin) is cleaved into the Golgi apparatus by the action of a prohormone convertase enzymes (PCs). Consequently immature CT (iCT) present in the secretory vesicle, undergoes further proteolytic cleavage to release mature CT (mCT). Chromogranin B may function as a helper protein to favor trans-Golgi sorting to the regulated secretory pathway.
