Table 1.

Analysis of ongoing somatic mutations and gene profiling in B cell diffuse large cell lymphoma (B-DLCL)

B-DLCL no.	Biopsy site	B-DLCL type by gene profiling	Most similar germ line VH gene	% Homology*	Tumor derived clones†/clones sequenced	No. of confirmed ongoing mutations	No. of molecular clones with ongoing mutations
0004	Thyroid	GCBL	1-03	89	16/16	2	3
0010	LN	GCBL	3-23	97	15/19	37	7
0012	Spleen	GCBL	3-30	87	19/19	8	3
0009	LN	GCBL	3-33	82	18/21	1	3
0015	LN	GCBL	3-48	90	14/27	1	2
0018	AT	GCBL	3-48	87	19/20	1‡	2
0026	LN	GCBL	3-11	90	18/20	1	8
0005	Lung	ABCL	1-f	82	9/17	0
0006	LN	ABCL	1-69	90	19/20	0
0011	LN	ABCL	3-23	90	21/21	1	2
0013	Lung	ABCL	3-23	96	19/19	0
0047	Stomach	ABCL	4-39	88	17/22	0
0021	LN	ABCL	4-34	99	15/15	0
0041	Skin	ABCL	4-34	97	15/15	1	2

LN, lymph node; AT, abdominal tumor; GCBL, germinal center B cell-like; ABCL, activated B cell-like. 

^*Percent V_H gene homology of the most abundant sequence. 

^†Clones sharing identical or near identical CDR3 sequence. 

^‡A deletion mutation causing out of frame Ig sequence.