Table 2.

Analysis of replacement (R) and silent (S) nonongoing somatic mutations in V_H CDRs and FRs of germinal center B cell like and ABCL-activated B cell-like diffuse large cell lymphoma (B-DLCL)

B-DLCL  no.	B-DLCL type by gene profiling	Most similar germ line VH gene	FR/CDR	Observed mutations		P value
				R	S
0004	GCBL	1-03	FR	19	5	NS
			CDR	7	2	NS
0010	GCBL	3-23	FR	4	3	NS
			CDR	3	0	NS
0012	GCBL	3-30	FR	11	7	<0.001
			CDR	15	4	0.001
0009	GCBL	3-33	FR	19	14	0.001
			CDR	17	2	0.006
0015	GCBL	3-48	FR	8	12	0.001
			CDR	4	4	NS
0018	GCBL	3-48	FR	6	10	<0.001
			CDR	19	3	<0.001
0026	GCBL	3-11	FR	14	6	NS
			CDR	7	3	NS
0005	ABCL	1-f	FR	27	10	NS
			CDR	13	3	NS
0006	ABCL	1-69	FR	10	10	0.002
			CDR	8	3	NS
0011	ABCL	3-23	FR	9	6	0.001
			CDR	11	4	0.006
0013	ABCL	3-23	FR	4	6	0.030
			CDR	3	0	NS
0047	ABCL	4-39	FR	14	14	0.016
			CDR	6	3	NS
0021	ABCL	4-34	FR	1	2	NS
			CDR	0	0
0041	ABCL	4-34	FR	4	2	NS
			CDR	2	0	NS

The P value is the probability that excess (for CDR) or scarcity (for FR) of mutations occurred by chance. Statistically nonsignificant values (P > 0.05) are marked as NS. GCBL, germinal center B cell like; ABCL, activated B cell-like; CDR, complementary determining region; FR, framework region.