TABLE 4.
Kinetic estimates of VLDL1 and VLDL2 apoB-100 in the CKD and control subjects as derived from model 1b
| CKD (n = 7) | Controls (n = 7) | P | |
|---|---|---|---|
| Plasma concentrations (mg/l) | |||
| Triglyceride | 150 (257) | 62 (35) | 0.004 |
| VLDL1 apoB | 17.0 [8.2, 94.4] | 8.4 [5.4, 18.1] | 0.035 |
| VLDL2 apoB | 65.3 [35.3, 277.6] | 34.5 [18.3, 57.6] | 0.013 |
| IDL apoB | 105.2 [39.6, 224.0] | 59.3 [32.5, 80.1] | 0.013 |
| LDL apoB | 811.7 [585.1, 1050.8] | 857.1 [669.4, 1029.6] | 0.34 |
| FCR (pools/day) | |||
| VLDL1 apoB | 10.8 [2.0, 25.7] | 29.5 [13.3, 70.3] | 0.009 |
| VLDL2 apoB | 5.4 [1.1, 8.5] | 10.4 [7.5, 14.4] | 0.003 |
| IDL apoB | 3.3 [1.9, 5.1] | 6.4 [4.5, 9.0] | 0.003 |
| LDL apoB | 0.38 [0.20, 0.58] | 0.47 [0.36, 0.56] | 0.3 |
| Production rate (mg/kg/day) | |||
| VLDL1 apoB | 9.5 [5.6, 17.5] | 13.0 [9.0, 19.7] | 0.18 |
| VLDL2 apoB | 15.4 (7.4) | 15.0 (3.4) | 0.95 |
| IDL apoB | 16.1 [11.3, 22.0] | 16.8 [12.2, 18.7] | 0.85 |
| LDL apoB | 14.1 [7.3, 19.8] | 17.8 [12.3, 21.5] | 0.08 |
| Conversion rate (%) | |||
| IDL to LDL apoB | 83.6 [59.1, 100.0] | 96.6 [83.0, 99.3] | 0.18 |
| VLDL1 to IDL apoB | 96.3 [55.1, 97.8] | 68.9 [7.8, 98.6] | 0.085 |
| VLDL1 to VLDL2 apoB | 96.7 [55.1, 97.8] | 68.9 [7.8, 98.6] | 0.085 |
| VLDL2 to IDL apoB | 100 [95.9, 100.0] | 100 [ - ] | 0.32 |
Data are presented as median (IQR). Kinetic data presented as median [minimum, maximum].